S Ghosh

S. Ghosh

Associate Professor Centre for Life Sciences

Biosensing and molecular diagnosis have a market size of USD 29 billion (2023) and are considered an area with enormous growth and commercial potential (CAGR 8%). This multidisciplinary field requires inputs from chemists, biologists, clinicians, physicists, electronics, and mechanical engineers. Dr Ghosh closely works with several collaborators from these fields and tries to build novel assays to enable and develop biosensing devices with biomedical, agricultural, and environmental applications.

Ph.D. (2009 – 2015)

Johns Hopkins University, Baltimore, USA

M.Sc. (2006 – 2008)

Indian Institute of Technology Madras, Chennai, India

B.Sc. (2003 – 2006)

Ramakrishna Mission Residential College Narendrapur (University of Calcutta), Kolkata, West Bengal, India

2023 – now

Associate Professor (2023 – now); Centre for Life Sciences, Mahindra University, Hyderabad, India

2022 – 2023

Scientist D (2022 – 2023); UGC-DAE CSR Kolkata Centre, Kolkata, India

2021 – 2022

Associate Professor (2021 – 2022); Bennett University, Greater Noida, India

2016 – 2021

Assistant Professor (2016 – 2021); Bennett University, Greater Noida, India

2015 – 2016

Postdoctoral Researcher (2015 – 2016); Cornell University, Ithaca, NY

2023

  • S Tripathy, T Agarkar, A Talukdar, M Sengupta, A Kumar*, S Ghosh**. Evaluation of indirect sequence-specific magneto-extraction-aided LAMP for fluorescence and electrochemical SARS-CoV-2 nucleic acid detection. Talanta. 2023, 252, 123809.

2022

  • T Agarkar, VK Nair, S Tripathy, V Chawla, S Ghosh, A Kumar.* Oxygen Vacancy Modulated MnO2 Bi-Electrode System for Attomole-Level Pathogen Nucleic Acid Sequence Detection, Electrochim Acta, 2022, 407, 139876.
  • S Tripathy, A Talukdar, PV Rajesh, G Pramanik*, S Ghosh*. Limited-Resource Preparable Chitosan Magnetic Particles for Extracting Amplification-Ready Nucleic Acid from Complex Biofluid. Analyst, 2022, 147, 165.
  • T Agarkar, S Tripathy, V Chawla, M Sengupta, S Ghosh*, A Kumar**. A batch processed titanium-vanadium oxide nanocomposite based solid-state electrochemical sensor for zeptomolar nucleic acid detection. Analytical Methods, 2022, 14, 4495.
  • S Kumar, A Kharb, A Vazirani, RS Chauhan, G Pramanik, M Sengupta, S Ghosh*. Nucleic acid extraction from complex biofluid using toothpick-actuated over-the-counter medical-grade cotton. Bioorg Med Chem. 2022, 73, 117009.
  • VK Nair, C Sharma, M Sengupta, S Ghosh*. Mitigating the Non-Specific Amplification in RCA: Assessment of the Role of Ligation and Exonuclease Digestion in Circular DNA Preparation. [in Revision]

2017

  • Long MJC, Poganik JR, Ghosh S, Aye Y. Subcellular Redox Targeting: Bridging In Vitro And In Vivo Chemical Biology. ACS Chem Biol. 2017, 12, 586-600.

2015

  • Xu W, Ouellette A, Ghosh S, O'Neill TC, Greenberg MM, Zhao L. Mutagenic Bypass Of An Oxidized Abasic Lesion-Induced DNA Interstrand Cross-Link Analogue By Human Translesion Synthesis DNA Polymerases. Biochemistry. 2015, 54, 7409-7422.
  • Xu W, Ghosh S, Ouellette A, Greenberg MM, Zhao L. Replication dependent DNA repair of DNA interstrand cross-links by human translesion DNA polymerases. Abstracts of Papers of the American Chemical Society. Volume 250 (conference presentation)
  • Ghosh, S.; Greenberg, M. M., Correlation of Thermal Stability and Structural Distortion of DNA Interstrand Cross-Links Produced from Oxidized Abasic Sites with Their Selective Formation and Repair. Biochemistry. 2015, 54, 6274-6283.

2014

  • Ghosh, S., Greenberg, M. M., Nucleotide Excision Repair Of Chemically Stabilized Analogues Of DNA Interstrand Cross-Links Produced From Oxidized Abasic Sites. Biochemistry 2014, 53, 5958-5965.
  • Ghosh, S., Greenberg, M. M., Synthesis of Cross-Linked DNA Containing Oxidized Abasic Site Analogues. J. Org. Chem. 2014, 79, 5948 - 5957. [**Featured article]
  • George, C., Ghosh, S., Chandrakumar, N., 29Si NMR-Transition Selective Double Quantum Filter Experiments In One And Two Dimensions. Future Directions in NMR; Editors: Khetrapal, C. L.; Kumar, A.; Ramanathan, K. V.; Springer, 2014, pp 231-237. (ISBN 978-81-8489-995-5)

Dr. Ghosh’s research lab currently focuses on the following areas;

  1. Instrument and method development to enable field-based near-point-of-care detection of pathogens
  2. Assay development for elucidating molecular DNA damage pathways
  3. Method development to better understand host-pathogen interaction at the molecular level
  4. Live biosensors

Research Area of Interest

  1. Cancer Biology Area 1: Early cancer detection and understanding the effect of radiotherapy
  2. Cancer Biology Area 2: Cancer therapeutics and augmenting radio-therapeutics using supplements
  3. Method and instrument development for biomarker detection

Openings

We work at the interface of medicine, biomaterials, and biochemistry. Along with conventional training, strong emphasis is put at collaborations, personalized mentoring, science communication, and industrial training. Following are encouraged to approach.

  • JRFs from DST INSPIRE
  • JRFs from ICMR / UGC / DBT / CSIR
  • RAs with postdoc fellowships like NPDF, ICMR, DBT RA etc.
  • 6 months MSc student thesis projects

For more details on our Science, please see our papers or write to us at souradyutighoshacademic@gmail.com
You can also visit the lab by contacting us in advance.

FUNDING (MONEY MATTERS!!)

The projects are kindly supported by

  • DST INSPIRE PhD fellowship 2023 for Ms Saba Parveen
  • DST Early career grant (2019-22)
  • DST Nanomission Nanobio category (2019-22)
  • DBT SARS-CoV-2 Detection grant (2020 – 2022)